protein SHMOOSE; small human mitochondrial ORF over serine tRNA

Function

• increases neural cell metabolic activity & mitochondrial oxygen consumption rate
• interacts with IMMT/mitofilin

Compartment

• mitochondria, nucleus
• detected in neuronal mitochondria & nuclei

Expression

• detected in cerebrospinal fluid (at protein level)

Pathology

• elevated expression in Alzheimer disease brains
• protects against cell death in vitro in neuronal cells stressed with oligomerized amyloid-beta protein 42

Comparative biology

• intracerebroventricular administration to the rat brain for 24 hours results in significant alterations to the hypothalamus transcriptome &, to a lesser extent, the hippocampus transcriptome

More general terms

• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/C0HM83.html