elinzanetant
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Introduction
Investigational
Indications
- vasomotor symptoms of menopause*
- improves sleep disturbances & menopause-related quality of life*
* elinzanetant with greater reduction in vasomotor symptom frequency & severity & improved sleep quality vs fezolinetant[2]
Dosage
Adverse effects
- headache & fatigue most common (7-9% vs 2.5-2.6% for placebo)
- no serious adverse effect in clinical trial[1]
Mechanism of action
- selective neurokinin-1,3 receptor antagonist
More general terms
References
- ↑ Jump up to: 1.0 1.1 Pinkerton JV, Simon JA, Joffe H et al Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause. OASIS 1 and 2 Randomized Clinical Trials. JAMA. Published online August 22, 2024. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39172446 https://jamanetwork.com/journals/jama/fullarticle/2822766
- ↑ Jump up to: 2.0 2.1 Menegaz de Almeida A, Oliveira P, Lopes L, et al. Fezolinetant and Elinzanetant Therapy for Menopausal Women Experiencing Vasomotor Symptoms: A Systematic Review and Meta-analysis. Obstet Gynecol. 2025 Jan 2 PMID: https://www.ncbi.nlm.nih.gov/pubmed/39746208