bronchodilator responsiveness

^[1]^[2]

Indications

component of pulmonary function test
conventional wisdom
- asthma have bronchodilator responsiveness
- patients with COPD have irreversible obstruction
in a large cohort, bronchodilator responsiveness failed to distinguish asthma & COPD

bronchodilator responses were more likely to be positive earlier in the day during the winter^[2]

↑ Beasley R et al. Prevalence, diagnostic utility and associated characteristics of bronchodilator responsiveness. Am J Respir Crit Care Med 2024 Feb 15; 209:390. PMID: https://pubmed.ncbi.nlm.nih.gov/38029294 PMCID: PMC10878375 Free PMC article https://www.atsjournals.org/doi/10.1164/rccm.202308-1436OC
↑ ^2.0 ^2.1 Knox-Brown B et al. Effect of time of day and seasonal variation on bronchodilator responsiveness: The SPIRO-TIMETRY study. Thorax 2025 Mar 11; PMID: https://pubmed.ncbi.nlm.nih.gov/40068921 Free article https://thorax.bmj.com/content/early/2025/03/11/thorax-2024-222773