Figure: urea cycle

Introduction

• urea cycle 1
  • enzyme: carbamoyl phosphate synthase NH3
  • substrate: CO2 + NH3 + 2 ATP
  • product: carbamoyl phosphate + 2 ADP + H2PO4-
• urea cycle 2
  • enzyme: ornithine carbamoyltransferase
  • substrate: ornithine + carbamoyl_phosphate
  • product: citrulline + H2PO4-
• urea cycle 3
  • enzyme: argininosuccinate synthetase
  • substrate: citrulline + aspartate + ATP
  • product: argininosuccinate + AMP + H2P2O7-2
• urea cycle 4
  • enzyme: argininosuccinate lyase
  • substrate: argininosuccinate
  • product arginine + fumarate
• urea cycle 5
  • enzyme: arginase-1
  • substrate: arginine + H2O
  • product: ornithine + urea