arginase-1 (hepatic arginase, ARG1)
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Introduction
Contributes 98% of activity in liver
Function
- nitrogen metabolism, urea cycle
- L-ornithine & urea from L-arginine: step 1/1
- 98% of arginase activity in liver
L-arginine + H2O <--> L-ornithine + urea
Cofactor: Mn+2
Structure
- homotrimer
- belongs to the arginase family
Compartment
Alternative splicing
named isoforms=3
Expression
induced by arginine or homoarginine
Pathology
- defects in ARG1 are the cause of argininemia
More general terms
Additional terms
References
- ↑ OMIM https://mirror.omim.org/entry/207800
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ARG1
- ↑ Wikipedia, Arginase entry http://en.wikipedia.org/wiki/Arginase
- ↑ UniProt http://www.uniprot.org/uniprot/P05089.html