Figure: coenzyme-A biosynthesis

Biochemistry

• coenzyme-A biosynthesis 1
  • enzyme: pantothenate kinase
  • substrate: pantothenate + ATP
  • product: 4-phosphopantothenate + ADP
• coenzyme-A biosynthesis 2
  • enzyme: phosphopantothenoylcysteine synthetase
  • substrate: 4-phosphopantothenate + ATP + cysteine
  • product: 4-phosphopantothenoylcysteine + ADP
• coenzyme-A biosynthesis 3
  • enzyme: phosphopantothenoyl-Cys-decarboxylase
  • substrate: 4-phosphopantothenoylcysteine
  • product: 4-phosphopantetheine + CO2
• coenzyme-A biosynthesis 4
  • enzyme: dephospho-CoA-pyrophosphorylase
  • substrate: 4-phosphopantetheine + ATP
  • product: dephosphocoenzyme-A + H2P2O7=
• coenzyme-A biosynthesis 5
  • enzyme: dephospho-CoA-kinase
  • substrate: 4-phosphopantetheine + ATP
  • product: coenzyme-A + ADP