lysine-specific demethylase 4F (KDM4F)

Function

• probable histone demethylase
• specifically demethylates 'Lys-9' of histone H3, thus playing a central role in histone code

2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[[[A130897|histone H3]]] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[[[A130897|histone H3]]] + 2 succinate

Cofactor: Fe+2 (binds 1 Fe+2 ion per subunit)

Structure

• belongs to the JHDM3 histone demethylase family

Compartment

nucleus

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/A0A1W2PPD8.html