alpha-synuclein seed amplification assay; CSF alpha-synuclein (SYNTap test)
Jump to navigation
Jump to search
Indications
- investigational assay for identifying alpha-synuclein pathology in limbic cortex & neocortex (sensitivity 97.8%, specificity 98.1%)
- useful for detecting lewy body dementia[1]
- CSF useful for detecting Parkinson's disease
- sensitivity 92.6%, specificity 90.5%[2][3]
- submandibular gland tissue for detecting Parkinson's disease*
- sensitivity 73.2%, specificity 78.6%[3]
* only 66% of assays for Parkinson's disease were positive for both CSF & submandibular gland[3]
Notes
- may be same as or component of alpha-synuclein aggregates in CSF
More general terms
Additional terms
- alpha synuclein aggregates in CSF; real-time quaking-induced conversion (RT-QuIC)
- alpha-synuclein; non-A beta component of AD amyloid; non-A4 component of amyloid; NACP (SNCA, NACP, PARK1)
Component of
References
- ↑ 1.0 1.1 Arnold MR et al. alpha-synuclein seed amplification in CSF and brain from patients with different brain distributions of pathological alpha-synuclein in the context of co-pathology and non-LBD diagnoses. Ann Neurol 2022 Jul 9; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/35808984 https://onlinelibrary.wiley.com/doi/10.1002/ana.26453
- ↑ 2.0 2.1 George J Parkinson's Biomarker Shows High Accuracy. Assay identifies hallmark protein and could help diagnose people earlier. MedPage Today April 12, 2023 https://www.medpagetoday.com/neurology/parkinsonsdisease/103990
Siderowf A, Concha-Marambio L, Lafontant DE et al Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using alpha-synuclein seed amplification: a cross- sectional study. Lancet Neurol. 2023 May;22(5):407-417. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37059509 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00109-6/fulltext - ↑ 3.0 3.1 3.2 3.3 Chahine LM, Beach TG, Adler CH et al. Central and peripheral alpha-synuclein in Parkinson disease detected by seed amplification assay. Ann Clin Transl Neurol 2023 Mar 27; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36972727 PMCID: PMC10187727 Free PMC article https://onlinelibrary.wiley.com/doi/10.1002/acn3.51753