alpha synuclein aggregates in skin

Indications

• evaluation of presymptomatic Parkinson's disease

Clinical significance

• may help diagnose Parkinson's s disease up to two decades before motor symptoms appear

Procedure

• direct stochastic optical reconstruction microscopy in connection with computational tools to image total & phosphorylated-alpha synuclein in skin biopsies

More general terms

• alpha synuclein Ag in tissue

Additional terms

• alpha-synuclein; non-A beta component of AD amyloid; non-A4 component of amyloid; NACP (SNCA, NACP, PARK1)

Components

• alpha-synuclein seed amplification assay; CSF alpha-synuclein (SYNTap test)