difelikefalin (Korsuva)

Indications

• treatment of moderate-severe pruritus in adults undergoing hemodialysis

Dosage

• 0.5. ug/kg IV bolus injection at the end of hemodialysis
• administer within 60 minutes of syringe preparation

Injection: 50 ug/mL

Adverse effects

• diarrhea, dizziness, nausea, gait disturbances, falls, hyperkalemia, headache, somnolence, mental status change

• drug adverse effects of opiates
• drug adverse effects of psychotropic agents
• drug adverse effects of sedatives

Mechanism of action

• kappa opioid receptor agonist

More general terms

• opioid receptor agonist (narcotic)