avacopan
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Indications
- ANCA-associated vasculitis
- adjunctive therapy to cyclophosphamide or rituximab*
* non-inferior to prednisone as adjunctive therapy
Dosage
Adverse effects
- infections, including opportunistic infections*
* prophylactic therapy for Pneumocystis jirovecii indicated
Mechanism of action
- C5a receptor (CD88) inhibitor
More general terms
References
- ↑ Jayne DRW, Merkel PA, Schall TJ, Bekker P for the ADVOCATE Study Avacopan for the Treatment of ANCA-Associated Vasculitis N Engl J Med 2021; 384:599-609. Feb 18 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33596356 https://www.nejm.org/doi/full/10.1056/NEJMoa2023386