UDP-glucuronosyltransferase 2A2; UDPGT 2A2; EC=2.4.1.17 (UGT2A2)

Function

• UDP-glucuronosyltransferase
• catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increasin metabolite water solubility, thus facilitating excretion into urine or bile
• essential for elimination & detoxification of drugs, xenobiotics & endogenous compounds
• catalyzes the glucuronidation of estradiol
• catalyzes glucuronidation of bile acids
• potential role in detoxification of toxic waste compounds in amniotic fluid

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H+ + UDP

Structure

belongs to the UDP-glycosyltransferase family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

mainly expressed in the nasal mucosa

Notes

• UGT2A2 isoform is part of the UGT2A complex locus which displays alternative use of promoters & exons.
• locus is defined by 2 alternative promoters resulting in 2 fonctionally active polypeptides UGT2A1 & UGT2A2
• alternative splicing of exons results in additional isoforms for each protein

More general terms

• UDP-glucuronosyltransferase-2 (UDPGT-2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=574537
• OMIM: https://mirror.omim.org/entry/604716
• UniProt: http://www.uniprot.org/uniprot/P0DTE5.html