UDP-glucuronosyltransferase 2A1; UDPGT 2A1 (UGT2A1, UGT2A2)

Function

• UDP-glucuronosyltransferase
• catalyzes phase II biotransformation reactions
• conjugation of odorants
• clearance of lipophilic odorant molecules from olfactory sensory epithelium

Structure

belongs to the UDP-glycosyltransferase family

Compartment

• membrane; single-pass type 1 membrane protein (putative)

Alternative splicing

named isoforms=3

Expression

• expressed in olfactory epithelium, brain & fetal lung
• not present in liver

Pharmacokinetics

• KM=75.4 uM for 3-hydroxybiphenyl
• KM=59.5 uM for umbelliferone
• KM=51.6 uM for S-(-)-b-citronellol
• KM=170.1 uM for borneol
• KM=56.2 uM for testosterone
• KM=251 uM for UDP-glucuronate
• Vmax=2.60 nmol/min/mg enzyme with 3-hydroxybiphenyl as substrate
• Vmax=0.61 nmol/min/mg enzyme with umbelliferone as substrate
• Vmax=1.98 nmol/min/mg enzyme with S-(-)-b-citronellol as substrate
• Vmax=1.05 nmol/min/mg enzyme with borneol as substrate
• Vmax=0.25 nmol/min/mg enzyme with testosterone as substrate

Notes

• UGT2A1 isoform is part of the UGT2A complex locus which displays alternative use of promoters & exons
• the locus is defined by 2 alternative promoters giving rise to 2 fonctionally active polypeptides UGT2A1 & UGT2A2
• alternative splicing of exons results in additional isoforms for each protein

More general terms

• UDP-glucuronosyltransferase-2A (UDPGT-2A)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10941
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=574537
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10941
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:574537
• OMIM: https://mirror.omim.org/entry/604716
• UniProt: http://www.uniprot.org/uniprot/P0DTE4.html