G antigen 4; cancer/testis antigen 4.4; CT4.4 (GAGE4)

Function

• antigen, recognized on melanoma by autologous cytotoxic T-cells

Structure

belongs to the GAGE family,

Expression

• expressed in testes & a variety of tumor tissues

Genetics

• belongs to a family of genes organized in clustered repeats with a high degree of predicted sequence identity, differing by scattered single nucleotide substitution
• their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

Notes

• product of a dubious gene prediction

More general terms

• uncharacterized protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2576
• UniProt: http://www.uniprot.org/uniprot/P0DSO3.html