pyrin domain-containing protein 5; pyrin domain-only protein 3 (PYDC5)

Function

• functions as an inhibitor of DNA virus-induced activation of AIM2-like receptors (ALR) inflammasome through interaction with AIM2
• interacts with AIM2
• disrupts assembly of the ALR inflammasome complex
• interacts with IFI16
• interacts with NLRP3

Expression

• expressed in monocytic cell lines & primary macrophages
• not expressed in B or T cells
• up-regulated in response to IFNB1 or virus infection

More general terms

• uncharacterized protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=107181
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:107181
• UniProt: http://www.uniprot.org/uniprot/W6CW81.html