perilipin-1; lipid droplet-associated protein-1 (PLIN1, PERI)

Function

• phosphorylated by cAMP dependent protein kinase
• unphosphorylated form may play role in inhibition of lipolysis by hormone sensitive lipase
• coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase
• absence may result in leanness
• major cAMP-dependent protein kinase-substrate in adipocytes
• dephosphorylated by PP1
• when phosphorylated, may be maximally sensitive to hormone sensitive lipase
• when unphosphorylated, may play a role in inhibition of lipolysis, by acting as a barrier in lipid droplet (putative)
• interacts with ABHD5 (putative)

Structure

belongs to the perilipin family

Compartment

• lipid droplet surface-associated (putative)

Expression

adipocytes

More general terms

• perilipin; lipid droplet-associated protein (PLIN)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5346
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5346
• OMIM: https://mirror.omim.org/entry/170290
• UniProt: http://www.uniprot.org/uniprot/O60240.html