blueberry
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Introduction
Components:
- ellagitannins, proanthocyanidins, anthocyanins, & other flavonoids
- pterostilbene
Pharmacokinetics
- ellagitannins, proanthocyanidins, anthocyanins, & other flavonoids in berrys are poorly absorbed & highly metabolized
- parent compounds, metabolites & conjugates detectable in human tissue Clinical manifestationw:
- discoloration of teeth & tongue
- blueberry consumption can improve endothelial function in healthy persons & at-risk populations[6]
- flavonoids including anthocyanins in blueberries may mitigate macular degeneration[6]
Clinical trials
- 12% improvement in memory over 2 year period in subjects age 50-84 consuming 1 cup of frozen blueberries/day; No study controls[2]
- lowers serum triglycerides (40%) & LDL cholesterol (20%)[3]
More general terms
References
- ↑ Seeram NP Dietary polyphenols from berry fruits: metabolism and health Aging: Mechanisms and Prevention 34th Annual Meeting of the American Aging Association June 3-6, 2005, Oakland CA
- ↑ 2.0 2.1 Raphaelson HA, Martin RJ et al Memory-score improvement observed during two-year blueberry study. Aging: Mechanisms and Prevention 34th Annual Meeting of the American Aging Association June 3-6, 2005, Oakland CA BlueberryStudy.com/measurements
- ↑ 3.0 3.1 Rimando A, USDA Proceedings of the 38th Annual Meeting of the American Aging Association: Integrative Biology: Hormones, Signaling, and Aging. May 29-June 1, 2009, Scottsdale, AZ
- ↑ McNamara D Blue' in Blueberries Tied to BP Lowering that Rivals Medication. Medscape - Mar 01, 2019. https://www.medscape.com/viewarticle/909717
Rodriguez-Mateos A et al Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics. J Gerontol A Biol Sci Med Sci. 2019 Jun 18;74(7):967-976 PMID: https://pubmed.ncbi.nlm.nih.gov/30772905 https://academic.oup.com/biomedgerontology/advance-article-abstract/doi/10.1093/gerona/glz047/5321875 - ↑ Bosch-Morell F, Villagrasa V, Ortega T et al Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration. Neural Regen Res. 2020 Dec;15(12):2207-2216. PMID: https://pubmed.ncbi.nlm.nih.gov/32594032 PMCID: PMC7749482 Free PMC article. Review.
- ↑ 6.0 6.1 6.2 Woolf EK, Lee SY, Ghanem N, Vazquez AR, Johnson SA. Protective effects of blueberries on vascular function: A narrative review of preclinical and clinical evidence. Nutr Res. 2023 Dec;120:20-57. PMID: https://pubmed.ncbi.nlm.nih.gov/37913730 Review.
- ↑ Martini D, Marino M, Venturi S et al Blueberries and their bioactives in the modulation of oxidative stress, inflammation and cardio/vascular function markers: a systematic review of human intervention studies. J Nutr Biochem. 2023 Jan;111:109154. PMID: https://pubmed.ncbi.nlm.nih.gov/36150681
- ↑ Wood E, Hein S, Mesnage R et al Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial. Am J Clin Nutr. 2023 Jun;117(6):1306-1319. doi:http://dx.doi.org/ 10.1016/j.ajcnut.2023.03.017. PMID: https://pubmed.ncbi.nlm.nih.gov/36972800 PMCID: PMC10315404 Free PMC article. Clinical Trial. https://pmc.ncbi.nlm.nih.gov/articles/PMC10315404/
- ↑ Kalt W, Cassidy A, Howard LR et al Recent Research on the Health Benefits of Blueberries and Their Anthocyanins. Adv Nutr. 2020 Mar 1;11(2):224-236. PMID: https://pubmed.ncbi.nlm.nih.gov/31329250 PMCID: PMC7442370 Free PMC article. Review. https://pmc.ncbi.nlm.nih.gov/articles/PMC7442370/