insulin aspart (NovoLog, Fiasp, Merilog)

Introduction

Synthetic proinsulin with more rapid onset & shorter duration of action than regular insulin, similar to insulin lispro.

Dosage

• may mix with NPH, but not other insulins

Pharmacokinetics

• absorbed faster after SQ injection than insulin, but slightly slower than Humalog

Mechanism of action

• 1 lysine & 1 proline residue of insulin substituted with aspartate residue

Notes

Novo Nordisk manufacturer

More general terms

• short-acting insulin

Additional terms

• lisproinsulin (Humalog, Lispro, Admelog, HumaPenn Memoir, HumaPenn Luxura HD, Humalog U-200 KwikPen)

Component of

• insulin degludec/insulin aspart
• insulin aspart/neutral protamine aspart (aspart 70/30)