emapalumab; emapalumab lzsg (Gamifant)

Indications

• primary hemophagocytic lymphohistiocytosis

Contraindications

• coadministration of live virus vaccine

Dosage

• 1 mg/kg IV infusion over 1 hour twice per week
• administer dexamethasone concomitantly
• 5 mg/mL; 2 mL, 10 mL

Monitor

• test for latent tuberculosis
• administer prophylactic treatment against Herpes zoster, Pneumocystis jirovecii

Mechanism of action

• inhibits IFN-gamma

More general terms

• pharmaceutical monoclonal antibody