polymerase proofreading-associated polyposis

Pathology

• features of both adenomatous polyposis coli (FAP) & Lynch syndrome
• associated with endmetrial cancer
• microsatellite instability

Genetics

• autosomal dominant
• associated with defects DNA polymerase proofreading genes POLE & POLD1

Management

• guidelines not yet established
  • follow guidelines for colorectal polyps

More general terms

• adenomatous polyposis syndrome