iridoviridae
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Introduction
double-stranded DNA viruses
Epidemiology
- amphibians, fish, invertebrates, lepidoptera, & orthoptera insects serve as natural hosts[1]
- found in human blood & feces[2]
Physiology
- genes produce peptide hormones that closely resemble human insulin & insulin-like growth factors[2]
- these peptides bind to human insulin receptor & IGF-1 receptor & stimulate downstream signaling
More general terms
References
- ↑ 1.0 1.1 Wikipedia: Iridoviridae https://en.wikipedia.org/wiki/Iridoviridae
- ↑ 2.0 2.1 2.2 Altindis E, Cai W, Sakaguchi M et al. Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions. Proc Natl Acad Sci U S A 2018 Mar 6; 115:2461. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29467286 <Internet> http://www.pnas.org/content/115/10/2461