J147
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Introduction
Experimental drug
Mechanism of action
- inhibits F1 ATPase alpha increasing intracellular Ca+2 resulting in sustained CAMKK2-dependent activation of the AMPK/mTOR pathway
Comparative biology
- benefit in mouse models of Alzheimer's disease
- extends life span of drosophila
More general terms
References
- ↑ Goldberg J, Currais A, Prior M et al The mitochondrial ATP synthase is a shared drug target for aging and dementia. Aging Cell. 2018 Jan 7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29316249 Free Article