pulmonary foreign body granulomatosis

Etiology

• injection or nasal inhalation of pulverized tablets, often opioids or stimulants, that contain inert fillers such as crospovidone, talc, or cellulose

Pathology

• perivascular aggregates of histiocytes & foreign-body giant cells with abundant basophilic foreign material in coral-like structures (histopathology)
  • mucicarmine staining

Diagnostic procedures

• lung-biopsy sample obtained by video-assisted thoracoscopic wedge resection (case report)

Radiology

• CT of chest (image)
  • diffuse, centrilobular nodules in both lungs

Management

• treatment of the underlying substance abuse disorder

More general terms

• granulomatosis