statins & Alzheimer's disease

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[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]

Introduction

Also see Statins & the risk of dementia

Notes

Additional terms

References

  1. ↑ Hoglund K, Wiklund O, Vanderstichele H, Eikenberg O, Vanmechelen E, Blennow K. Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins. Arch Neurol. 2004 Mar;61(3):333-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15023808
  2. ↑ Lutjohann D, von Bergmann K. 24S-hydroxycholesterol: a marker of brain cholesterol metabolism. Pharmacopsychiatry. 2003 Sep;36 Suppl 2:S102-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14574622
  3. ↑ Wagstaff LR, Mitton MW, Arvik BM, Doraiswamy PM. Statin-associated memory loss: analysis of 60 case reports and review of the literature. Pharmacotherapy. 2003 Jul;23(7):871-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12885101
  4. ↑ Baskin F, Rosenberg RN, Fang X, Hynan LS, Moore CB, Weiner M, Vega GL. Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients. Neurology. 2003 Jun 24;60(12):2006-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12821755
  5. ↑ Sjogren M, Gustafsson K, Syversen S, Olsson A, Edman A, Davidsson P, Wallin A, Blennow K. Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein. Dement Geriatr Cogn Disord. 2003;16(1):25-30. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12714796
  6. ↑ Vega GL, Weiner MF, Lipton AM, Von Bergmann K, Lutjohann D, Moore C, Svetlik D. Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease. Arch Neurol. 2003 Apr;60(4):510-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12707064
  7. ↑ Kirsch C, Eckert GP, Mueller WE. Statin effects on cholesterol micro-domains in brain plasma membranes. Biochem Pharmacol. 2003 Mar 1;65(5):843-56. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12628479
  8. ↑ Bays HE, Stein EA, Shah AK, Maccubbin DL, Mitchel YB, Mercuri M. Effects of simvastatin on C-reactive protein in mixed hyperlipidemic and hypertriglyceridemic patients. Am J Cardiol. 2002 Nov 1;90(9):942-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12398959
  9. ↑ Simons M, Schwarzler F, Lutjohann D, von Bergmann K, Beyreuther K, Dichgans J, Wormstall H, Hartmann T, Schulz JB. Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial. Ann Neurol. 2002 Sep;52(3):346-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12205648
  10. ↑ Wiklund O, Mattsson-Hulten L, Hurt-Camejo E, Oscarsson J. Effects of simvastatin and atorvastatin on inflammation markers in plasma. J Intern Med. 2002 Apr;251(4):338-47. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11952885
  11. ↑ Fassbender K, Simons M, Bergmann C, Stroick M, Lutjohann D, Keller P, Runz H, Kuhl S, Bertsch T, von Bergmann K, Hennerici M, Beyreuther K, Hartmann T. Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5856-61. Epub 2001 Apr 10. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11296263
  12. ↑ 12.0 12.1 Pedrini S, Carter TL, Prendergast G, Petanceska S, Ehrlich ME, Gandy S. Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK. PLoS Med. 2005 Jan;2(1):e18. Epub 2005 Jan 11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15647781
  13. ↑ 13.0 13.1 Haag MDM et al Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study. J Neurol Neurosurg Psychiatry 2009 Jan; 80:13. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18931004
  14. ↑ 14.0 14.1 Sano M et al. A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease. Neurology 2011 Aug 9; 77:556 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21795660
  15. ↑ 15.0 15.1 McGuinness B, Craig D, Bullock R, Passmore P. Statins for the prevention of dementia. Cochrane Database Syst Rev. 2016;1:CD003160 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26727124
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