tezepelumab-ekko (Tezspire)
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Indications
- uncontrolled asthma in adults (FDA-approved for severe asthma)
- adjunctive treatment with long-acting beta-agonists & inhaled glucocorticoids
- added to SQ immunotherapy for allergic rhinitis due to cat allergies[4]
* reduces exacerbations, improves lung function, controls asthma control, & improves health-related quality of life in patients with severe, uncontrolled asthma[2]
Dosage
Mechanism of action
- inhibits thymic stromal lymphopoietin (TSLP)
More general terms
References
- ↑ Corren J, Parnes JR, Wang L et al Tezepelumab in Adults with Uncontrolled Asthma N Engl J Med 2017; 377:936-946. September 7, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28877011 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1704064
Bel EH. Moving upstream - Anti-TSLP in persistent uncontrolled asthma. N Engl J Med 2017 Sep 7; 377:989. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28877024 <Internet> http://www.nejm.org/doi/10.1056/NEJMe1709519 - ↑ 2.0 2.1 Menzies-Gow A, Corren J, BourdinA et al Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma. N Engl J Med 2021; 384:1800-1809. May 13 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33979488 https://www.nejm.org/doi/full/10.1056/NEJMoa2034975
- ↑ Helio FDA approves tezepelumab for severe asthma https://www.healio.com/news/pulmonology/20211220/fda-approves-tezepelumab-for-severe-asthma
Larkin HD News From the Food and Drug Administration Therapy Approved for All Types of Severe Asthma JAMA. 2022;327(9):805 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35230413 https://jamanetwork.com/journals/jama/fullarticle/2789564 - ↑ 4.0 4.1 Janeczko JL Add Tezepelumab to SCIT to Improve Cat Allergy Symptoms? Medscape. Nov 18, 2022 https://www.medscape.com/viewarticle/984335
- ↑ Corren J, Menzies-Gow A, Chupp G, et al. Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials. Am J Respir Crit Care Med. 2023 Jul 1;208(1):13-24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37015033