fibrillarin (U3 RNP) Ab in serum

Epidemiology

• more common in black men Pinciple:
• anti-fibrillarin Ab

Clinical significance

• associated with poor outcomes in scleroderma
  • scleroderma complicated by pulmonary hypertension
  • diffuse cutaneous scleroderma
  • scleroderma complicated by myositis
    • speckled antinuclear antibody pattern

More general terms

• RNP Ab in serum

More specific terms

• fibrillarin (U3 RNP) IgG in serum

Additional terms

• rRNA 2'-O-methyltransferase fibrillarin; 34 kD nucleolar scleroderma antigen (FBL, FIB1, FLRN)
• U3-snRNP; U3 small nuclear ribonucleoprotein