asfotase alfa (Strensiq)

Indications

• perinatal, infantile & juvenile-onset hypophosphatasia

Dosage

• injection 3-6 times per week

Injection: 100 mg/mL (0.8 mL), 40 mg/mL (0.45, 0.7, 1 mL)

Adverse effects

• most common
  • injection site reactions
  • hypersensitivity reactions
    • dypnea, nausea, dizziness, fever
  • lipodystrophy
  • ectopic calcifications of the eyes & kidney

Mechanism of action

• replaces tissue-nonspecific alkaline phosphatase

More general terms

• metabolic agent (metabolic modifier)
• recombinant protein; chimer