alkaline phosphatase-L (liver/kidney/bone, tissue-nonspecific alkaline phosphatase, ALPL)

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Function

phosphate monoester + H2O <--> an alcohol + phosphate

Cofactor:

  • binds 1 Mg+2 (putative)
  • binds 2 Zn+2 (putative)

Structure

Compartment

cell membrane, lipid-anchor, GPI-anchor

Pathology

Pharmacology

Laboratory

Notes

More general terms

Additional terms

References

  1. OMIM https://mirror.omim.org/entry/171760
  2. ALPL, Tissue nonspecific alkaline phosphatase gene mutations database http://www.sesep.uvsq.fr/Database.html
  3. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ALPL
  4. Wikipedia; note=alkaline phosphatase entry http://en.wikipedia.org/wiki/alkaline_phosphatase
  5. UniProt http://www.uniprot.org/uniprot/P05186.html
  6. 6.0 6.1 FDA News Release. October 23, 2015 FDA approves new treatment for rare metabolic disorder. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm468836.htm

Database