cast nephropathy
Jump to navigation
Jump to search
Etiology
Pathology
- nephrotoxic light chain are filtered & accumulate in the renal tubules resultin in tubular injury & formation of casts within the renal tubules
Laboratory
- urine protein: proteinuria other than albuminuria
- urine protein electrophoresis
- urinalysis
- urinary casts
- bland urine sediment
- renal biopsy Mamagement:
- intravenous fluids
- avoidance of nephrotoxic agents
- chemotherapy to reduce free light chain burden[1]
- plasmapheresis clears free light chains inefficiently[1]