cyclic citrullinated peptide antibody in serum; anti-citrulline antibody in serum; anti-CCP in serum
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Indications
Clinical significance
- 70% sensitivity for RA; specificity for RA 95%
- anti-CCP is less sensitive than rheumatoid factor (RF), but more specific for RA (95% vs 85-90%)*
- may be elevated in rheumatoid factor-negative rheumatoid arthritis
- anti-CCP positive in 40-60% of patients early in the course of RA when RF may be negative[3]
- presence of rheumatoid factor & anti-CCP Ab makes diagnosis of RA more likely[5]
- presence associated with erosions
- predicts disease progression in undifferentiated arthritis[3]
- levels > 3-fold upper limit of normal associated with increased risk for development of rheumatoid arthritis[6]
* anti-CCP Ab may occur in
- rheumatologic disease other than rheumatoid arthritis
- active tuberculosis
- chronic lung disease[5]
More general terms
More specific terms
- cyclic citrullinated peptide (CCP) IgA Ab in serum/plasma
- cyclic citrullinated peptide (CCP) IgA+IgG Ab in serum/plasma
- cyclic citrullinated peptide (CCP) IgG Ab in serum/plasma
Additional terms
References
- ↑ CCP Lab Tests Online: http://www.labtestsonline.org/understanding/analytes/ccp/glance.html
- ↑ Shmerling RH Testing for anti-cyclic citrullinated peptide antibodies: is it time to set this genie free? Arch Intern Med. 2009 Jan 12;169(1):9-14. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19139318
- ↑ Jump up to: 3.0 3.1 3.2 Medical Knowledge Self Assessment Program (MKSAP) 14, 16, 17. American College of Physicians, Philadelphia 2006, 2012, 2015
- ↑ Whiting PF, Smidt N, Sterne JA et al Systematic review: accuracy of anti-citrullinated Peptide antibodies for diagnosing rheumatoid arthritis. Ann Intern Med. 2010 Apr 6;152(7):456-64; W155-66 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20368651
- ↑ Jump up to: 5.0 5.1 5.2 Veterans Administration
- ↑ Jump up to: 6.0 6.1 Ford JA, Liu X, Marshall AA et al. Impact of cyclic citrullinated peptide antibody level on progression to rheumatoid arthritis in clinically tested cyclic citrullinated peptide antibody-positive patients without rheumatoid arthritis. Arthritis Care Res (Hoboken) 2019 Dec; 71:1583. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30570827 https://onlinelibrary.wiley.com/doi/abs/10.1002/acr.23820
Patient information
cyclic citrullinated peptide antibody (CCP) patient information