versican core protein; large fibroblast proteoglycan; chondroitin sulfate proteoglycan core protein 2; PG-M; Glial hyaluronate-binding protein; GHAP (VCAN CSPG2)
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Function
- may play a role in intercellular signaling & in connecting cells with the extracellular matrix
- may take part in regulation of cell motility, growth & differentiation
- binds hyaluronic acid
- interacts with FBLN1 (putative)
Structure
- belongs to the aggrecan/versican proteoglycan family
- contains 1 C-type lectin domain
- contains 2 EGF-like domains
- contains 1 Ig-like V-type domain (immunoglobulin-like)
- contains 2 link domains
- contains 1 Sushi (CCP/SCR) domain
Compartment
Alternative splicing
named isoforms=5; V0,V1,V2,V3,vint Additional isoforms seem to exist
Expression
- expressed in cerebral white matter
- isoform V0 & isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, & meningiomas
- isoform V2 is restricted to normal brain & gliomas
- isoform V3 is found in all these tissues except medulloblastomas
- expression disappears after cartilage development
Pathology
- defects in VCAN are the cause of Wagner syndrome type 1
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P13611.html
- ↑ Functional glycomics gateway - glycan binding - Note: versican http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_214
- ↑ Ruoslahti E, Yamaguchi Y. Proteoglycans as modulators of growth factor activities. Cell. 1991 Mar 8;64(5):867-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2001586