histone H2A-like 3; H2A.L.3 (H2AL3, H2AL1RP)

Function

• core component of nucleosome
• nucleosomes wrap & compact DNA into chromatin, limiting DNA accessibility to cellular machinery which requires DNA as a template
• histones thus play a central role in transcription regulation, DNA repair, DNA replication & chromosomal stability
• DNA accessibility is regulated via a complex set of post-translational modifications of histones (histone code), & nucleosome remodeling
• the nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 & H4 assembled in one H3-H4 heterotetramer & two H2A-H2B heterodimers
• the octamer wraps approximately 147 bp of DNA

Structure

belongs to the histone H2A family,

Compartment

nucleus . chromosome

More general terms

• histone

Database

• UniProt: http://www.uniprot.org/uniprot/A0A3B3IU63.html