histone H2A.N; H2B.N; H2B.N variant histone 1 (H2BN1)
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Function
- core component of nucleosome
- nucleosomes wrap & compact DNA into chromatin, limiting DNA accessibility to cellular machinery which requires DNA as a template
- histones thus play a central role in transcription regulation, DNA repair, DNA replication & chromosomal stability
- DNA accessibility is regulated via a complex set of post-translational modifications of histones (histone code), & nucleosome remodeling
- the nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 & H4 assembled in one H3-H4 heterotetramer & two H2A-H2B heterodimers
- the octamer wraps approximately 147 bp of DNA
Structure
belongs to the histone H2B family,