POLG alternative reading frame; POLGARF; ORF-Y; contains:, POLGARF C-terminal fragment; POLGARFin (POLGARF)

Function

• undergoes proteolytic cleavage to produce a secreted C-terminal fragment
• interacts with C1QBP;
  • the interaction results in nucleolar localization of C1QBP, probably due to prevention of C1QBP maturation & redirection from mitochondria to nucleoli

Compartment

• [POLG alternative reading frame]: nucleus, nucleolus
• [POLGARF C-terminal fragment]: secreted

Notes

• encoded by an alternative reading frame in the POLG gene
• translation initiation occurs at a non-canonical CUG codon

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/A0A3B3IS91.html