pregnanediol in 24 hour urine

Indications

• evaluation of
  • pregnancy
    • placental insufficiency
    • pre-eclampsia
  • precocious puberty
  • congenital adrenal hyperplasia
  • growth hormone-secreting pituitary adenoma
  • granulosa theca cell tumors
  • arrhenoblastoma
  • chorioepithelioma
  • luteal cyst
  • ovarian failure

Reference interval

• < 0.1 mg/day 0-2 years
• < 0.3 mg/day 3-5 years
• < 0.6 mg/day 6-9 years
• < 0.7 mg/day 10-15 years male
• < 1.3 mg/day 10-15 years female
• < 1.9 mg/day adult male
• < 2.6 mg/day adult female (follicular phase)
• < 10.6 mg/day adult female (luteal phase)
• 10-35 mg/day pregnant female 1st trimester
• 35-70 mg/day pregnant female 2nd trimester
• 70-100 mg/day pregnant female 3rd trimester

Increases

• precocious puberty
• growth hormone-secreting pituitary adenoma
• chorioepithelioma
• congenital adrenal hyperplasia caused by steroid 17-alpha hydroxylase deficiency & steroid 11-beta hydroxylase deficiency
• granulosa theca cell tumors
• luteal cyst
• arrhenoblastoma

Decreases

• placental insufficiency
• pre-eclampsia
• ovarian failure

More general terms

• 24 hour urine
• pregnanediol in urine

Additional terms

• pregnanediol