screening for hyperhomocysteinemia
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Indications
- atherosclerosis without conventional risk factors
- premature atherosclerosis (before age 60)
- high risk for premature atherosclerosis
- 1st degree relative with premature atherosclerosis
- tobaccoism
- hypertension
- chronic renal failure
- unexplained deep vein thrombosis (DVT)
- systemic lupus erythematosus
- severe psoriasis
- recipients of solid organ transplant
- pharmacologic agents elevating plasma homocysteine levels
* screening should be deferred until 8 weeks after recovery from serious systemic illness