adoptive cell transfer

^[1]

Indications

CD8+ & CD4+ T cells are extracted from a patient's tumor tissue & cultured to large numbers
CD8+ & CD4+ T cells are then stimulated to attack tumor cells more aggressively, & reinfused into the patient
often, a patient's lymphocyte population is depleted by chemotherapy prior to reintroduction of the amplified & stimulated CD8+ & CD4+ T cells
in the absence of other lymphocytes, the reintrocdued CD8+ & CD4+ T cells proliferate rapidly^[1]

↑ ^1.0 ^1.1 ^1.2 Komaroff AL Immunotherapy to Fight Cancer Begins to Work. NEJM Journal Watch. June 16, 2015 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
Rosenberg SA and Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science 2015 Apr 3; 348:62 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25838374
June CH et al. Adoptive cellular therapy: A race to the finish line. Sci Transl Med 2015 Mar 25; 7:280ps7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25810311