cytochrome P450 2D7 (CYP2D7)

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[1][2][3][4][5]

Function

  • may be responsible for the metabolism of many drugs & environmental chemicals that it oxidizes
  • conflicting reports on role in metabolism of codeine to morphine[2][3]
RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O

Cofactor: heme

Structure

Compartment

Expression

  • expressed in brain cortex (at protein level)

Polymorphism

  • conflicting reports of a rare double polymorphism giving rise to expression of a functional protein[2][4][5]

Notes

could be the product of a pseudogene

More general terms

References

  1. ↑ UniProt http://www.uniprot.org/uniprot/A0A087X1C5.html
  2. ↑ 2.0 2.1 2.2 PMID: https://pubmed.ncbi.nlm.nih.gov/15051713
  3. ↑ 3.0 3.1 PMID: https://pubmed.ncbi.nlm.nih.gov/18838503
  4. ↑ 4.0 4.1 PMID: https://pubmed.ncbi.nlm.nih.gov/16169517
  5. ↑ 5.0 5.1 PMID: https://pubmed.ncbi.nlm.nih.gov/17494644

Database

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