triosephosphate isomerase (TIM, triose-phosphate isomerase) (TPI1 TPI)

Function

• catalyzes interconversion of glyceraldehyde-3-phosphate & dihydroxyacetone phosphate
• carbohydrate biosynthesis; gluconeogenesis
• carbohydrate degradation; glycolysis
• D-glyceraldehyde 3-phosphate from glycerone phosphate, step 1/1

D-glyceraldehyde-3-phosphate <--> glycerone-phosphate

Structure

• homodimer
• belongs to the triosephosphate isomerase family

Alternative splicing

named isoforms=2 (Alternative splicing seems doubtful, since exon-intron junctions are not the consensus ones)

Pathology

• defects in TPI1 are the cause of triosephosphate isomerase deficiency

More general terms

• isomerase
• glycolytic enzyme
• oligomerizing protein
• phosphoprotein

Additional terms

• gluconeogenesis
• glycolytic pathway (glycolysis, Embden Myerhof pathway)

Database

• OMIM: https://mirror.omim.org/entry/190450
• UniProt: http://www.uniprot.org/uniprot/P60174.html