BDNF genotyping

^[1]

Clinical significance

BDNF Val66Val polymorphism most common (68%)
elderly with the BDNF Val66Val polymorphism benefit greatly from physical activity^[1]
- greater physical activity levels were associated with larger volumes in the temporal lobe & hippocampus
elderly with BDNF Val66Met polymorphism did not benefit from exercise
- greater physical activity was associated with smaller temporal-lobe volume^[1]

↑ ^1.0 ^1.1 ^1.2 Brown BM et al. Influence of BDNF Val66Met on the relationship between physical activity and brain volume. Neurology 2014 Oct 7; 83:1345 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25186863