LINE-1 retrotransposable element ORF2 protein; ORF2p; includes: reverse transcriptase; endonuclease

Function

• has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition
• has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA
• cleaves DNA in AT-rich regions between a 5' stretch of purines & a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome

Structure

• contains 1 DUF1725 domain
• contains 1 reverse transcriptase domain

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/O00370.html