apelin receptor early endogenous ligand; protein elabela; protein Toddler (APELA, ELA, TDL)

Function

• hormone required during early development for endoderm differentiation & heart morphogenesis
• acts as a ligand for the apelin receptor (APLNR) & promotes its internalization
• acts as a motogen by promoting endoderm & mesendoderm cell migration during gastrulation via the apelin receptor
• role during heart development via the apelin receptor
• interacts with APLNR (putative)

Structure

• belongs to the elabela/Toddler family

Compartment

• secreted, extracellular space

Expression

• highest expression in undifferentiated embryonic stem cells
• rapidly down-regulated during differentiation

More general terms

• receptor
• secreted protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/615594
• UniProt: http://www.uniprot.org/uniprot/P0DMC3.html