genome sequencing
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Notes
- notes from earlier years may show progress in clinical implementation of whole genome sequencing
- whole-genome sequencing in addition to standard family history of unclear value[2]
- results of whole-genome sequencing initiate inappropriate clinical actions
- the US National Institutes of Health (NIH) recently launched the All of Us initiative intended to bring gene sequencing technology to > 1 million people in the US[3]
- strong buy-in by organizational leadership of integrating genome sequence data into health care may ultimately lead to improvements in population health[3]
- development & implementation of population-scale clinical genome sequencing programs in health care systems present new opportunities for generation of robust evidence regarding the benefits, harms, & economic value associated with precision medicine[3]
- potential exists for creation of new data sharing models across institutions, harmonization of data standards, & the development of novel, validated metrics for outcomes related to the application of precision medicine in populations[3]
More general terms
More specific terms
- Ashkenazi jewish genomic sequence analysis
- breast cancer-related disorders genomic sequencing
- fetal chromosomal aneuploid genomic sequencing
- hearing loss genomic sequencing
- hereditary colon cancer syndrome genomic sequencing
- lymphoid disorder genomic sequence analysis
- mitochondrially encoded genomic sequence panel
- neuroendocrine tumor genomic sequencing
- Noonan syndrome genomic sequence analysis
- retinal disorders genomic sequencing
- whole exome sequence analysis
- whole genome sequence analysis
- X-linked intellectual disability genomic sequence analysis
Additional terms
References
- ↑ Dewey FE et al Clinical interpretation and implications of whole-genome sequencing. JAMA 2014 Mar 12; 311:1035. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24618965
Feero WG. Clinical application of whole-genome sequencing: Proceed with care. JAMA 2014 Mar 12; 311:1017 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24618961 - ↑ 2.0 2.1 Vassy JL, Christensen KD, Schonman EF et al The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial. Ann Intern Med. June 27, 2017. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28654958 <Internet> http://annals.org/aim/article/2633848/impact-whole-genome-sequencing-primary-care-outcomes-healthy-adult-patients
Manolio TA Incorporating Whole-Genome Sequencing Into Primary Care: Falling Barriers and Next Steps. Ann Intern Med. June 27, 2017. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28654971 <Internet> http://annals.org/aim/article/2635325/incorporating-whole-genome-sequencing-primary-care-falling-barriers-next-steps - ↑ 3.0 3.1 3.2 3.3 3.4 Feero WG, Wicklund CA, Veenstra D. Precision Medicine, Genome Sequencing, and Improved Population Health. JAMA. Published online March 16, 2018. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29547675 https://jamanetwork.com/journals/jama/fullarticle/2675723