disorders with neurofibrillary tangles

Introduction

NFT are seen in neurons of patients with various disorders, including:

• aging*
• Alzheimer's disease*
• Down's syndrome*
• ALS Parkinson-dementia complex of Guam
• postencephalitic parkinsonism
• dementia pugilistica
• Hallervorden-Spatz disease
• progressive supranuclear palsy
• subacute sclerosing panencephalitis [SSPE]
• adult neuronal ceroid lipofuscinosis (Kufs' disease)

* Neuritic plaques are also observed in these disorders.

Additional terms

• adult neuronal ceroid lipofuscinosis/cerebral sphingolipidosis (Kufs type)
• aging
• Alzheimer's disease (AD)
• amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam
• dementia pugilistica
• Down's syndrome
• Hallervorden-Spatz disease; pantothenate kinase associated neurodegeneration (PKAN); neurodegeneration with brain iron accumulation type 1 (NBIA1); pigmentary pallidal degeneration
• post-encephalitic parkinsonism
• progressive supranuclear palsy; Steele-Richardson-Olszewski syndrome (PSP)
• subacute sclerosing panencephalitis (Dawson disease, SSPE)