NSAID nephropathy

Introduction

Also see analgesic nephropathy (chronic interstitial nephritis)

Etiology

• NSAID-induced injury is more likely to occur in patients who are volume-depleted
• more likely to occur in patients with hypercalcemia
• patients with multiple myeloma are at increased risk

Pathology

• reduced renal blood flow secondary to intrarenal vasoconstriction
• reduced glomerular filtration rate
• pyuria
• minimal change disease +/- chronic interstitial nephritis
• papillary necrosis
• membranous nephropathy
• nephrotic syndrome
• hyperkalemia & type IV renal tubular acidosis (RTA)
• hyponatremia
• fluid retention
  • Na+ retention
  • may exacerbate congestive heart failure (CHF)

Laboratory

• active urinary sediment
• increased serum creatinine

More general terms

• nephropathy

Additional terms

• non-steroidal anti-inflammatory agent (NSAID)