lipomatosis

Epidemiology

rare

Pathology

• benign condition

Genetics

• autosomal dominant
• genetic aberration in HMGA2
• chromosomal translocation t(3;12)(q27-q28;q13-q15) involving HMGA2 with LPP is associated with lipomatosis

Clinical manifestations

• multiple encapsulated lipomas form on the trunk & extremities, with relatively few on the head & shoulders

Differential diagnosis

• other entities are associated with multiple lipomas
  • Proteus syndrome
  • Cowden syndrome
  • disorders due to PTEN gene mutations,
    • benign symmetric lipomatosis (Madelung disease)
    • familial lipodystrophy
    • hibernomas
    • familial angiolipomatosis

Management

• cosmetic: excision vs liposuction

More general terms

• lipid disorder (dyslipidemia)
• skin disease (dermatologic disorder, dermatopathy, dermatosis)