eukaryotic translation initiation factor 2D (EIF2D)

Function

• translation initiation factor
• able to deliver tRNA to the P-site of the eukaryotic ribosome (GTP-independent)
• binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes during initiation complex formation on some specific RNAs
• activity in tRNA binding with 40S subunits does not require the aminoacyl moiety
• unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit
• in addition to its role in initiation, can promote release of deacylated tRNA & mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits

Structure

• belongs to the eIF2D family
• contains 1 PUA domain
• contains 1 SUI1 domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• found during embryonic development & in early differentiated states

More general terms

• initiation factor
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P41214.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1939
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1939
• OMIM: https://mirror.omim.org/entry/151625