dichlorodiphenyltrichloroethane; chlorophenothane; clofenotane (DDT)

^[1]^[2]^[3]^[4]

Introduction

higher serum levels of metabolite DDE associated with increased risk & increased severity of Alzheimer's disease^[2]
- HR=3 with highest tertile of serum levels of DDE^[2]
probably carcinogenic to humans^[3]
- increased risk for non-Hodgkin's lymphoma, testicular cancer, & liver cancers^[3]
prenatal exposure linked to increased risk of autism in offspring^[4]

↑ PubChem: 3036
↑ ^2.0 ^2.1 ^2.2 Richardson JR et al Elevated Serum Pesticide Levels and Risk for Alzheimer Disease. JAMA Neurol. Published online January 27, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24473795 <Internet> http://archneur.jamanetwork.com/article.aspx?articleid=1816015
DeKosky ST and Gandy S Environmental Exposures and the Risk for Alzheimer Disease. Can We Identify the Smoking Guns? JAMA Neurol. Published online January 27, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24473699 <Internet> http://archneur.jamanetwork.com/article.aspx?articleid=1816013
↑ ^3.0 ^3.1 ^3.2 World Health Organization (WHO). Press Release. June 2015 International Agency for Research on Cancer. IARC Monographs evaluate DDT, lindane, and 2,4-D http://www.iarc.fr/en/media-centre/pr/2015/pdfs/pr236_E.pdf
↑ ^4.0 ^4.1 Brown AS, Cheslack-Postava K, Rantakokko P et al Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort. Am J Psychiatry. Aug 16, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30111184 https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.17101129
American Psychiatric Association. Aug 16, 2018 Study Links Mothers' Pesticide Levels with Autism in Children. https://www.psychiatry.org/newsroom/news-releases/study-links-mothers-pesticide-levels-with-autism-in-children