atypical chemokine receptor; chemokine-scavenging receptor; chemokine decoy receptor

Introduction

Fuunction:

• controls chemokine levels & localization via high-affinity chemokine binding uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis
• also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor
• acts as a receptor for chemokines
• chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization

More general terms

• G-protein coupled receptor; serpentine receptor
• chemokine receptor (chemoattractant receptor)

More specific terms

• atypical chemokine receptor 2; C-C chemokine receptor 10; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine receptor CCR-9; chemokine-binding protein 2; chemokine-binding protein D6 (ACKR2, CCBP2, CCR10, CMKBR9, D6)
• atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1 (ACKR3, CMKOR1, CXCR7, GPR159, RDC1)
• atypical chemokine receptor 4; C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCRL1; CCX CKR (ACKR4, CCBP2, CCR11, CCRL1 ,VSHK1)