multivesicular body subunit 12B; ESCRT-I complex subunit MVB12B; protein FAM125B (MVB12B, C9orf28, FAM125B)

Function

• component of the ESCRT-1 complex, a regulator of vesicular trafficking process
• required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies
• interacts with TSG101, VPS37B & VPS37C
  • associations appear to be mediated by the TSG101-VPS37 binary subcomplex
• interacts with VPS28
• interacts with VPS37B

Structure

• belongs to the MVB12 family
• contains 1 MABP domain
• contains 1 UMA domain

Compartment

• endosome (probable)l late endosome membrane

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein

Component of

• ESCRT-1 complex; endosomal sorting complex required for transport 1

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89853
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:89853
• UniProt: http://www.uniprot.org/uniprot/Q9H7P6.html